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Impairment of the ubiquitin-proteasome pathway is a downstream ER stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic β-cell apoptosis
Human islet amyloid polypeptide (hIAPP) aggregation plays a major role in the development of islet amyloidosis in type 2 diabetes mellitus. It is known that extracellular hIAPP oligomers are toxic to pancreatic β-cells and associated with apoptosis. OBJECTIVE: To investigate the molecular mechanism...
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| Publicado en: | Diabetes |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7217710/ https://ncbi.nlm.nih.gov/pubmed/17563070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-0178 |
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