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Puma is required for p53-induced depletion of adult stem cells
Mammalian ageing is accompanied by accumulation of genomic DNA damage and progressive decline in the ability of tissues to regenerate1. DNA damage activates the tumour suppressor p53, which leads to cell-cycle arrest, senescence or apoptosis. The stability and activity of p53 are induced by DNA dama...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3025300/ https://ncbi.nlm.nih.gov/pubmed/20818388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2100 |
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