Opposing Action of Casein Kinase 1 and Calcineurin in Nucleo-cytoplasmic Shuttling of Mammalian Translation Initiation Factor eIF6

Eukaryotic initiation factor 6 (eIF6), a highly conserved protein from yeast to mammals, is essential for 60 S ribosome biogenesis and assembly. Both yeast and mammalian eIF6 are phosphorylated at Ser-174 and Ser-175 by the nuclear isoform of casein kinase 1 (CK1). The molecular basis of eIF6 phosph...

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Autors principals: Biswas, Arunima, Mukherjee, Shaeri, Das, Supratik, Shields, Dennis, Chow, Chi Wing, Maitra, Umadas
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Protein Synthesis and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024805/
https://ncbi.nlm.nih.gov/pubmed/21084295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.188565
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