LPS Impairs Phospholipid Synthesis by Triggering β-Transducin Repeat-containing Protein (β-TrCP)-mediated Polyubiquitination and Degradation of the Surfactant Enzyme Acyl-CoA:Lysophosphatidylcholine Acyltransferase I (LPCAT1)

Acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a relatively newly described and yet indispensable enzyme needed for generation of the bioactive surfactant phospholipid, dipalmitoylphosphatidylcholine (DPPtdCho). Here, we show that lipopolysaccharide (LPS) causes LPCAT1 degradation us...

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Autores principales: Zou, Chunbin, Butler, Phillip L., Coon, Tiffany A., Smith, Rebecca M., Hammen, Gary, Zhao, Yutong, Chen, Bill B., Mallampalli, Rama K.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Lipids
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024768/
https://ncbi.nlm.nih.gov/pubmed/21068446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.192377
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