LPS Impairs Phospholipid Synthesis by Triggering β-Transducin Repeat-containing Protein (β-TrCP)-mediated Polyubiquitination and Degradation of the Surfactant Enzyme Acyl-CoA:Lysophosphatidylcholine Acyltransferase I (LPCAT1)

Acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a relatively newly described and yet indispensable enzyme needed for generation of the bioactive surfactant phospholipid, dipalmitoylphosphatidylcholine (DPPtdCho). Here, we show that lipopolysaccharide (LPS) causes LPCAT1 degradation us...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Zou, Chunbin, Butler, Phillip L., Coon, Tiffany A., Smith, Rebecca M., Hammen, Gary, Zhao, Yutong, Chen, Bill B., Mallampalli, Rama K.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2011
Θέματα:
Lipids
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024768/
https://ncbi.nlm.nih.gov/pubmed/21068446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.192377
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