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Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains
Argonaute and Piwi proteins are key players in the RNA silencing pathway, with the former interacting with micro-RNAs (miRNAs) and siRNAs, whereas the latter targets piwi-interacting RNAs (piRNAs) that are 2′-O-methylated (2(′)-OCH(3)) at their 3′ ends. Germline-specific piRNAs and Piwi proteins pla...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024652/ https://ncbi.nlm.nih.gov/pubmed/21193640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017762108 |
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