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Marginal zone B cell production of pathogenic natural antibodies is CR2 dependent but C3 independent
Intestinal ischemia/reperfusion (IR)-induced damage requires complement receptor 2 (CR2) for generation of the appropriate natural antibody repertoire. Pathogenic antibodies recognize neo-antigens on the ischemic tissue, activate complement and induce intestinal damage. As C3 cleavage products act a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024465/ https://ncbi.nlm.nih.gov/pubmed/21187447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002059 |
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