CDK1 PARTICIPATES IN BRCA1-DEPENDENT S PHASE CHECKPOINT CONTROL IN RESPONSE TO DNA DAMAGE

Cdk2 and cdk1 are individually dispensable for cell cycle progression in cancer cell lines because they are able to compensate for one another. However, shRNA-mediated depletion of cdk1 alone or small molecule cdk1 inhibition abrogated S phase cell cycle arrest and the phosphorylation of a subset of...

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Autori principali: Johnson, Neil, Cai, Dongpo, Kennedy, Richard D., Pathania, Shailja, Arora, Mansi, Li, Yu-Chen, D’Andrea, Alan D., Parvin, Jeffrey D., Shapiro, Geoffrey I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024055/
https://ncbi.nlm.nih.gov/pubmed/19683496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.06.036
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