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The contribution of -arginine to the neurotoxicity of recombinant tissue plasminogen activator following cerebral ischemia: a review of rtPA neurotoxicity
Alteplase is the only drug licensed for acute ischemic stroke, and in this formulation, the thrombolytic agent recombinant tissue plasminogen activator (rtPA) is stabilized in a solution of -arginine. Improved functional outcomes after alteplase administration have been shown in clinical trials, alo...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3023931/ https://ncbi.nlm.nih.gov/pubmed/20736961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.149 |
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