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The contribution of -arginine to the neurotoxicity of recombinant tissue plasminogen activator following cerebral ischemia: a review of rtPA neurotoxicity

Alteplase is the only drug licensed for acute ischemic stroke, and in this formulation, the thrombolytic agent recombinant tissue plasminogen activator (rtPA) is stabilized in a solution of -arginine. Improved functional outcomes after alteplase administration have been shown in clinical trials, alo...

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Bibliografski detalji
Glavni autori: Harston, George W J, Sutherland, Brad A, Kennedy, James, Buchan, Alastair M
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023931/
https://ncbi.nlm.nih.gov/pubmed/20736961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.149
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