Azido-Iodo-N-Benzyl Derivatives of threo-Methylphenidate (Ritalin, Concerta): Rational Design, Synthesis, Pharmacological Evaluation, and Dopamine Transporter Photoaffinity Labeling

In contrast to tropane-based compounds such as benztropine and cocaine, non-tropane-based photoaffinity ligands for the dopamine transporter (DAT) are relatively unexplored. Towards addressing this knowledge gap, ligands were synthesized in which the piperidine nitrogen of 3- and 4-iodomethylphenida...

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Главные авторы: Lapinsky, David J., Velagaleti, Ranganadh, Yarravarapu, Nageswari, Liu, Yi, Huang, Yurong, Surratt, Christopher K., Lever, John R., Foster, James D., Acharya, Rejwi, Vaughan, Roxanne A., Deutsch, Howard M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023924/
https://ncbi.nlm.nih.gov/pubmed/21129986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.11.002
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