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Proinflammatory Adjuvants Enhance the Cognate Helper Activity of Aged CD4 T Cells

Age-related declines in humoral responses contribute to the reduced efficacy of vaccines in older populations. Using an adoptive transfer model, we have shown that age-related intrinsic declines in CD4 T cell function contribute significantly to the reduced humoral responses observed with aging, res...

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Bibliografiske detaljer
Main Authors: Maue, Alexander C., Eaton, Sheri M., Lanthier, Paula A., Sweet, Kathryn B., Blumerman, Seth L., Haynes, Laura
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023905/
https://ncbi.nlm.nih.gov/pubmed/19414765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804226
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