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Use of Yeast Chemigenomics and COXEN Informatics in Preclinical Evaluation of Anticancer Agents

Bladder cancer metastasis is virtually incurable with current platinum-based chemotherapy. We used the novel COXEN informatic approach for in silico drug discovery and identified NSC-637993 and NSC-645809 (C1311), both imidazoacridinones, as agents with high-predicted activity in human bladder cance...

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Detalhes bibliográficos
Main Authors: Smith, Steven C, Havaleshko, Dmytro M, Moon, Kihyuck, Baras, Alexander S, Lee, Jae, Bekiranov, Stefan, Burke, Daniel J, Theodorescu, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023847/
https://ncbi.nlm.nih.gov/pubmed/21253455
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