Intranasal immunization with plasmid DNA encoding spike protein of SARS-coronavirus/polyethylenimine nanoparticles elicits antigen-specific humoral and cellular immune responses

BACKGROUND: Immunization with the spike protein (S) of severe acute respiratory syndrome (SARS)-coronavirus (CoV) in mice is known to produce neutralizing antibodies and to prevent the infection caused by SARS-CoV. Polyethylenimine 25K (PEI) is a cationic polymer which effectively delivers the plasm...

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Bibliografski detalji
Glavni autori: Shim, Byoung-Shik, Park, Sung-Moo, Quan, Ji-Shan, Jere, Dhananjay, Chu, Hyuk, Song, Man Ki, Kim, Dong Wook, Jang, Yong-Suk, Yang, Moon-Sik, Han, Seung Hyun, Park, Yong-Ho, Cho, Chong-Su, Yun, Cheol-Heui
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023737/
https://ncbi.nlm.nih.gov/pubmed/21194475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-11-65
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