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Plasmid DNA Vaccine Co-Immunisation Modulates Cellular and Humoral Immune Responses Induced by Intranasal Inoculation in Mice

BACKGROUND: An effective HIV vaccine will likely require induction of both mucosal and systemic cellular and humoral immune responses. We investigated whether intramuscular (IM) delivery of electroporated plasmid DNA vaccine and simultaneous protein vaccinations by intranasal (IN) and IM routes coul...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: King, Deborah F. L., McKay, Paul F., Mann, Jamie F. S., Jones, C. Bryn, Shattock, Robin J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636430/
https://ncbi.nlm.nih.gov/pubmed/26544970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141557
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