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Transcription and replication: Breaking the rules of the road causes genomic instability
Replication and transcription machineries progress at high speed on the same DNA template, which inevitably causes traffic accidents. Problems are not only caused by frontal collisions between polymerases, but also by cotranscriptional R-loops. These RNA-DNA hybrids induce genomic instability by blo...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Landes Bioscience
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3023637/ https://ncbi.nlm.nih.gov/pubmed/21326900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/trns.1.2.12665 |
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