Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages

Palmitic acid (PA) upregulates oxidized LDL receptor-1 (LOX-1), a scavenger receptor responsible for uptake of oxidized LDL (oxLDL), and enhances oxLDL uptake in macrophages. However, the precise underlying mechanism remains to be elucidated. PA is known to induce endoplasmic reticulum (ER) stress i...

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Main Authors: Ishiyama, Junichi, Taguchi, Ryoko, Akasaka, Yunike, Shibata, Saiko, Ito, Minoru, Nagasawa, Michiaki, Murakami, Koji
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023550/
https://ncbi.nlm.nih.gov/pubmed/21078775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M007104
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