Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis

C(6)-pyridinium (d-erythro-2-N-[6′-(1′′-pyridinium)-hexanoyl]sphingosine bromide [LCL29]) is a cationic mitochondrion-targeting ceramide analog that promotes mitochondrial permeabilization and cancer cell death. In this study, we compared the biological effects of that compound with those of d-eryth...

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Hauptverfasser: Hou, Qi, Jin, Junfei, Zhou, Hui, Novgorodov, Sergei A., Bielawska, Alicja, Szulc, Zdzislaw M., Hannun, Yusuf A., Obeid, Lina M., Hsu, Yi-Te
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2011
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023548/
https://ncbi.nlm.nih.gov/pubmed/21081756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M012161
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