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A Novel Motif in the Crohn's Disease Susceptibility Protein, NOD2, Allows TRAF4 to Down-regulate Innate Immune Responses

The Crohn's disease and early onset sarcoidosis susceptibility protein, NOD2, coordinates innate immune signaling pathways. Because dysregulation of this coordination can lead to inflammatory disease, maintaining appropriate activation of the NOD2 signaling pathway is paramount in immunologic h...

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Bibliografiske detaljer
Main Authors: Marinis, Jill M., Homer, Craig R., McDonald, Christine, Abbott, Derek W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023490/
https://ncbi.nlm.nih.gov/pubmed/21097508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.189308
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