Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease

The X-linked inhibitor of apoptosis (XIAP) protein has been identified as a key genetic driver of two distinct inflammatory disorders, X-linked lymphoproliferative syndrome 2 (XLP-2) and very-early-onset inflammatory bowel disease (VEO-IBD). Molecularly, the role of XIAP mutations in the pathogenesi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Chirieleison, Steven M., Marsh, Rebecca A., Kumar, Prathna, Rathkey, Joseph K., Dubyak, George R., Abbott, Derek W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465490/
https://ncbi.nlm.nih.gov/pubmed/28404814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.781500
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