Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

The potent lipid mediator sphingosine-1-phosphate (S1P) regulates diverse physiological processes by binding to 5 specific GPCRs, although it also has intracellular targets. Here, we demonstrate that S1P, produced in the mitochondria mainly by sphingosine kinase 2 (SphK2), binds with high affinity a...

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Autori principali: Strub, Graham M., Paillard, Melanie, Liang, Jie, Gomez, Ludovic, Allegood, Jeremy C., Hait, Nitai C., Maceyka, Michael, Price, Megan M., Chen, Qun, Simpson, David C., Kordula, Tomasz, Milstien, Sheldon, Lesnefsky, Edward J., Spiegel, Sarah
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2011
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023391/
https://ncbi.nlm.nih.gov/pubmed/20959514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-167502
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