Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice

Cytochrome P-450 (CYP)-derived epoxyeicosatrienoic acids (EETs) possess potent anti-inflammatory effects in vitro. However, the effect of increased CYP-mediated EET biosynthesis and decreased soluble epoxide hydrolase (sEH, Ephx2)-mediated EET hydrolysis on vascular inflammation in vivo has not been...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Deng, Yangmei, Edin, Matthew L., Theken, Katherine N., Schuck, Robert N., Flake, Gordon P., Kannon, M. Alison, DeGraff, Laura M., Lih, Fred B., Foley, Julie, Bradbury, J. Alyce, Graves, Joan P., Tomer, Kenneth B., Falck, John R., Zeldin, Darryl C., Lee, Craig R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2011
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023387/
https://ncbi.nlm.nih.gov/pubmed/21059750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-171488
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge