Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice

Cytochrome P-450 (CYP)-derived epoxyeicosatrienoic acids (EETs) possess potent anti-inflammatory effects in vitro. However, the effect of increased CYP-mediated EET biosynthesis and decreased soluble epoxide hydrolase (sEH, Ephx2)-mediated EET hydrolysis on vascular inflammation in vivo has not been...

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Autori principali: Deng, Yangmei, Edin, Matthew L., Theken, Katherine N., Schuck, Robert N., Flake, Gordon P., Kannon, M. Alison, DeGraff, Laura M., Lih, Fred B., Foley, Julie, Bradbury, J. Alyce, Graves, Joan P., Tomer, Kenneth B., Falck, John R., Zeldin, Darryl C., Lee, Craig R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2011
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023387/
https://ncbi.nlm.nih.gov/pubmed/21059750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-171488
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