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Mice expressing ouabain-sensitive α1-Na,K-ATPase have increased susceptibility to pressure overload-induced cardiac hypertrophy

The Na,K-ATPase is a ubiquitous transmembrane pump and a specific receptor for cardiac glycosides such as ouabain and digoxin, which are used in the management of congestive heart failure (CHF). A potential role for these so-called endogenous cardiotonic steroids (CS) has been explored, and it has b...

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Autors principals: Wansapura, Arshani N., Lasko, Valerie M., Lingrel, Jerry B, Lorenz, John N.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023246/
https://ncbi.nlm.nih.gov/pubmed/20952666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00625.2010
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