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Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1β

The proinflammatory cytokine IL-18 was investigated for its role in human myocardial function. An ischemia/reperfusion (I/R) model of suprafused human atrial myocardium was used to assess myocardial contractile force. Addition of IL-18 binding protein (IL-18BP), the constitutive inhibitor of IL-18 a...

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Main Authors: Pomerantz, Benjamin J., Reznikov, Leonid L., Harken, Alden H., Dinarello, Charles A.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC30232/
https://ncbi.nlm.nih.gov/pubmed/11226333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.041611398
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