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A Single Amino Acid Substitution Makes WNK4 Susceptible to SB 203580 and SB 202190

Regulation of the SLC12 family of membrane transporters including NCCT involves a scaffold of interacting proteins including the STE 20 kinase SPAK and the WNK kinases, WNK 1 and WNK 4, which are mutated in the hypertensive syndrome of pseudohypoaldosteronism type 2 (PHAII). WNK4 regulates NCCT by a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Glover, Mark, Sweeney, Connor, Davis, Bill, O’Shaughnessy, Kevin M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Bentham Open 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023092/
https://ncbi.nlm.nih.gov/pubmed/21249167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1874104501004010057
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