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A Single Acidic Residue Can Guide Binding Site Selection but Does Not Govern QacR Cationic-Drug Affinity

Structures of the multidrug-binding repressor protein QacR with monovalent and bivalent cationic drugs revealed that the carboxylate side-chains of E90 and E120 were proximal to the positively charged nitrogens of the ligands ethidium, malachite green and rhodamine 6G, and therefore may contribute t...

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Main Authors: Peters, Kate M., Brooks, Benjamin E., Schumacher, Maria A., Skurray, Ronald A., Brennan, Richard G., Brown, Melissa H.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022030/
https://ncbi.nlm.nih.gov/pubmed/21264225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015974
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