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QacR−Cation Recognition Is Mediated by a Redundancy of Residues Capable of Charge Neutralization†

[Image: see text] The Staphylococcus aureus multidrug binding protein QacR binds to a broad spectrum of structurally dissimilar cationic, lipophilic drugs. Our previous structural analyses suggested that five QacR glutamic acid residues are critical for charge neutralization and specification of cer...

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Detalhes bibliográficos
Main Authors: Peters, Kate M., Schuman, Jason T., Skurray, Ronald A., Brown, Melissa H., Brennan, Richard G., Schumacher, Maria A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2008
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646753/
https://ncbi.nlm.nih.gov/pubmed/18616285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8008246
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