Enhanced Platelet Activation Mediates the Accelerated Angiogenic Switch in Mice Lacking Histidine-Rich Glycoprotein

BACKGROUND: The heparin-binding plasma protein histidine-rich glycoprotein (HRG; alternatively, HRGP/HPRG) can suppress tumor angiogenesis and growth in vitro and in vivo. Mice lacking the HRG gene are viable and fertile, but have an enhanced coagulation resulting in decreased bleeding times. In add...

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Detalhes bibliográficos
Main Authors: Ringvall, Maria, Thulin, Åsa, Zhang, Lei, Cedervall, Jessica, Tsuchida-Straeten, Nobuko, Jahnen-Dechent, Willi, Siegbahn, Agneta, Olsson, Anna-Karin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022027/
https://ncbi.nlm.nih.gov/pubmed/21264222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014526
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