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Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors
Tumors are characterized by leaky blood vessels, and by an abnormal and heterogeneous vascular network. These pathophysiological characteristics contribute to the enhanced permeability and retention (EPR) effect, which is one of the key rationales for developing tumor-targeted drug delivery systems....
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| Publicado no: | J Control Release |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6130770/ https://ncbi.nlm.nih.gov/pubmed/29730154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.05.002 |
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