Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors

Tumors are characterized by leaky blood vessels, and by an abnormal and heterogeneous vascular network. These pathophysiological characteristics contribute to the enhanced permeability and retention (EPR) effect, which is one of the key rationales for developing tumor-targeted drug delivery systems....

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Foilsithe in:J Control Release
Main Authors: Theek, Benjamin, Baues, Maike, Gremse, Felix, Pola, Robert, Pechar, Michal, Jahnen-Dechent, Willi, Storm, Gert, Kiessling, Fabian, Lammers, Twan
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130770/
https://ncbi.nlm.nih.gov/pubmed/29730154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.05.002
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