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Allele-selective inhibition of huntingtin expression by switching to an miRNA-like RNAi mechanism

Inhibiting expression of huntingtin (HTT) protein is a promising strategy for treating Huntington’s Disease (HD), but indiscriminant inhibition of both wild-type and mutant alleles may lead to toxicity. An ideal silencing agent would block expression of mutant HTT while leaving expression of wild-ty...

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Bibliografiske detaljer
Main Authors: Hu, Jiaxin, Liu, Jing, Corey, David R.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021381/
https://ncbi.nlm.nih.gov/pubmed/21095568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.10.013
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