The Pim protein kinases regulate energy metabolism and cell growth

The serine/threonine Pim kinases are overexpressed in solid cancers and hematologic malignancies and promote cell growth and survival. Here, we find that a novel Pim kinase inhibitor, SMI-4a, or Pim-1 siRNA blocked the rapamycin-sensitive mammalian target of rapamycin (mTORC1) activity by stimulatin...

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Main Authors: Beharry, Zanna, Mahajan, Sandeep, Zemskova, Marina, Lin, Ying-Wei, Tholanikunnel, Baby G., Xia, Zuping, Smith, Charles D., Kraft, Andrew S.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021022/
https://ncbi.nlm.nih.gov/pubmed/21187426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013214108
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