Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast

Evolving lineages face a constant intracellular threat: most new coding sequence mutations destabilize the folding of the encoded protein. Misfolded proteins form insoluble aggregates and are hypothesized to be intrinsically cytotoxic. Here, we experimentally isolate a fitness cost caused by toxicit...

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Detaylı Bibliyografya
Asıl Yazarlar: Geiler-Samerotte, Kerry A., Dion, Michael F., Budnik, Bogdan A., Wang, Stephanie M., Hartl, Daniel L., Drummond, D. Allan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021021/
https://ncbi.nlm.nih.gov/pubmed/21187411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017570108
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