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LC/MS evaluation of metabolism and membrane transport of bombesin peptides

Two bombsin peptides, GRPR agonist [Aca-QWAVGHLM-NH(2)] and antagonist [fQWAVGHL-NHEthyl] were evaluated. We employed the highly sensitive Waters Q-Tof Premier MS coupled with a UPLC system to identify the metabolites produced by rat hepatocytes or PC-3 human prostate cancer cells; and we utilized t...

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Main Authors: Gu, Dongyu, Ma, Ying, Niu, Gang, Yan, Yongjun, Lang, Lixin, Aisaand, Haji Akber, Gao, Haokao, Kiesewetter, Dale O., Chen, Xiaoyuan
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020998/
https://ncbi.nlm.nih.gov/pubmed/20676905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-010-0696-y
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