Cross-Regulation between Oncogenic BRAF(V600E) Kinase and the MST1 Pathway in Papillary Thyroid Carcinoma

BACKGROUND: The BRAF(V600E) mutation leading to constitutive signaling of MEK-ERK pathways causes papillary thyroid cancer (PTC). Ras association domain family 1A (RASSF1A), which is an important regulator of MST1 tumor suppressor pathways, is inactivated by hypermethylation of its promoter region i...

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Hlavní autoři: Lee, Seong Jin, Lee, Min Hee, Kim, Dong Wook, Lee, SeongEun, Huang, Songmei, Ryu, Min Jeong, Kim, Yong Kyung, Kim, Sung Jin, Kim, Soung Jung, Hwang, Jung Hwan, Oh, Sangphil, Cho, Heeyeong, Kim, Jin Man, Lim, Dae-Sik, Jo, Young Suk, Shong, Minho
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020965/
https://ncbi.nlm.nih.gov/pubmed/21249150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016180
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