Cross-Regulation between Oncogenic BRAF(V600E) Kinase and the MST1 Pathway in Papillary Thyroid Carcinoma

BACKGROUND: The BRAF(V600E) mutation leading to constitutive signaling of MEK-ERK pathways causes papillary thyroid cancer (PTC). Ras association domain family 1A (RASSF1A), which is an important regulator of MST1 tumor suppressor pathways, is inactivated by hypermethylation of its promoter region i...

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Detalhes bibliográficos
Main Authors: Lee, Seong Jin, Lee, Min Hee, Kim, Dong Wook, Lee, SeongEun, Huang, Songmei, Ryu, Min Jeong, Kim, Yong Kyung, Kim, Sung Jin, Kim, Soung Jung, Hwang, Jung Hwan, Oh, Sangphil, Cho, Heeyeong, Kim, Jin Man, Lim, Dae-Sik, Jo, Young Suk, Shong, Minho
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020965/
https://ncbi.nlm.nih.gov/pubmed/21249150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016180
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