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Homodimerization of Nemo-like kinase is essential for activation and nuclear localization

Nemo-like kinase (NLK) is an evolutionarily conserved protein kinase that phosphorylates several transcription factors. However, the molecular mechanisms that regulate NLK activity have been poorly understood. Here we show that homodimerization of NLK is required for its activation and nuclear local...

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Bibliografiske detaljer
Main Authors: Ishitani, Shizuka, Inaba, Kenji, Matsumoto, Kunihiro, Ishitani, Tohru
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020921/
https://ncbi.nlm.nih.gov/pubmed/21118996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-07-0605
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