Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats

The reactive advanced glycation end product (AGE) precursor methylglyoxal (MGO) and MGO-derived AGEs are associated with diabetic vascular complications and also with an increase in oxidative stress. Glyoxalase-I (GLO-I) transgenic rats were used to explore whether overexpression of this MGO detoxif...

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Hauptverfasser: Brouwers, Olaf, Niessen, Petra M., Ferreira, Isabel, Miyata, Toshio, Scheffer, Peter G., Teerlink, Tom, Schrauwen, Patrick, Brownlee, Michael, Stehouwer, Coen D., Schalkwijk, Casper G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020745/
https://ncbi.nlm.nih.gov/pubmed/21056979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.144097
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