Antitumor Activity of Hu14.18-IL2 in Patients With Relapsed/Refractory Neuroblastoma: A Children's Oncology Group (COG) Phase II Study

PURPOSE: The hu14.18-IL2 fusion protein consists of interleukin-2 molecularly linked to a humanized monoclonal antibody that recognizes the GD2 disialoganglioside expressed on neuroblastoma cells. This phase II study assessed the antitumor activity of hu14.18-IL2 in two strata of patients with recur...

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Hauptverfasser: Shusterman, Suzanne, London, Wendy B., Gillies, Stephen D., Hank, Jacquelyn A., Voss, Stephan D., Seeger, Robert C., Reynolds, C. Patrick, Kimball, Jennifer, Albertini, Mark R., Wagner, Barrett, Gan, Jacek, Eickhoff, Jens, DeSantes, Kenneth B., Cohn, Susan L., Hecht, Toby, Gadbaw, Brian, Reisfeld, Ralph A., Maris, John M., Sondel, Paul M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Clinical Oncology 2010
Schlagworte:
Original Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020698/
https://ncbi.nlm.nih.gov/pubmed/20921469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.27.8861
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