Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch

Two transcription factors, Pax5 and Blimp-1, form a gene regulatory network (GRN) with a double-negative loop, which defines either B-cell (Pax5 high) or plasma cell (Blimp-1 high) status as a binary switch. However, it is unclear how this B-cell GRN registers class switch DNA recombination (CSR), a...

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Main Authors: Muto, Akihiko, Ochiai, Kyoko, Kimura, Yoshitaka, Itoh-Nakadai, Ari, Calame, Kathryn L, Ikebe, Dai, Tashiro, Satoshi, Igarashi, Kazuhiko
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020649/
https://ncbi.nlm.nih.gov/pubmed/20953163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.257
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