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Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch
Two transcription factors, Pax5 and Blimp-1, form a gene regulatory network (GRN) with a double-negative loop, which defines either B-cell (Pax5 high) or plasma cell (Blimp-1 high) status as a binary switch. However, it is unclear how this B-cell GRN registers class switch DNA recombination (CSR), a...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3020649/ https://ncbi.nlm.nih.gov/pubmed/20953163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.257 |
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