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The use of the SAEM algorithm in MONOLIX software for estimation of population pharmacokinetic-pharmacodynamic-viral dynamics parameters of maraviroc in asymptomatic HIV subjects

Using simulated viral load data for a given maraviroc monotherapy study design, the feasibility of different algorithms to perform parameter estimation for a pharmacokinetic-pharmacodynamic-viral dynamics (PKPD-VD) model was assessed. The assessed algorithms are the first-order conditional estimatio...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Chan, Phylinda L. S., Jacqmin, Philippe, Lavielle, Marc, McFadyen, Lynn, Weatherley, Barry
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer US 2010
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020311/
https://ncbi.nlm.nih.gov/pubmed/21088872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-010-9175-z
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