Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion.

5-Fluorodeoxyuridine monophosphate (FdUMP), the active metabolite of 5-fluorouracil (5-FU), is a tight-binding inhibitor of thymidylate synthetase, the enzyme which converts dUMP to TMP. Newly developed assays for FdUMP and dUMP were utilized to assess the competitive roles played by these nucleotid...

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Bibliografski detalji
Glavni autori: Myers, C E, Young, R C, Chabner, B A
Format: Artigo
Jezik:Inglês
Izdano: 1975
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC301986/
https://ncbi.nlm.nih.gov/pubmed/1184747
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