In vitro biochemical and in vivo biological studies of the uridine 'rescue' of 5-fluorouracil.

The effect of delayed uridine administration on the in vitro growth inhibitory effects of 5-fluorouracil (5FU) and on the in vivo antitumour activity and toxicity was studied. In vitro growth inhibition of the human intestinal cell lines WiDr and Intestine 407 by 3 microM 5FU could be reversed by 1....

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Detalhes bibliográficos
Main Authors: Peters, G. J., van Dijk, J., Laurensse, E., van Groeningen, C. J., Lankelma, J., Leyva, A., Nadal, J. C., Pinedo, H. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1988
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2246507/
https://ncbi.nlm.nih.gov/pubmed/3355763
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