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Roles of Residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in Extended-Spectrum β-Lactamase Toho-1

Toho-1, which is also designated CTX-M-44, is an extended-spectrum class A β-lactamase that has high activity toward cefotaxime. In this study, we investigated the roles of residues suggested to be critical for the substrate specificity expansion of Toho-1 in previous structural analyses. Six amino...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Shimizu-Ibuka, Akiko, Oishi, Mika, Yamada, Shoko, Ishii, Yoshikazu, Mura, Kiyoshi, Sakai, Hiroshi, Matsuzawa, Hiroshi
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019690/
https://ncbi.nlm.nih.gov/pubmed/21078949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00098-10
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