Oral Hexadecyloxypropyl-Cidofovir Therapy in Pregnant Guinea Pigs Improves Outcome in the Congenital Model of Cytomegalovirus Infection

Cytomegalovirus (CMV) infection is the leading cause of congenital infection, producing both sensorineural hearing loss and mental retardation. We evaluated the in vivo efficacy of an orally bioavailable analog of cidofovir, hexadecyloxypropyl-cidofovir (HDP-CDV), against guinea pig CMV (GPCMV) in a...

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Auteurs principaux: Bravo, Fernando J., Bernstein, David I., Beadle, James R., Hostetler, Karl Y., Cardin, Rhonda D.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2011
Sujets:
Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019685/
https://ncbi.nlm.nih.gov/pubmed/21078944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00971-10
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