An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity

Caspases are key mediators in liver inflammation and apoptosis. In the present study we provide evidence that a nitric oxide (NO) derivative of ursodeoxycholic acid (UDCA), NCX-1000 ([2-(acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester]), protects against liver damage in murine models of autoim...

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Detalles Bibliográficos
Main Authors: Fiorucci, Stefano, Mencarelli, Andrea, Palazzetti, Barbara, Del Soldato, Piero, Morelli, Antonio, Ignarro, Louis J.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC30193/
https://ncbi.nlm.nih.gov/pubmed/11226294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.041603898
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