Loss of the AE3 Anion Exchanger in a Hypertrophic Cardiomyopathy Model Causes Rapid Decompensation and Heart Failure

The AE3 Cl(−)/HCO(3)(−) exchanger is abundantly expressed in the sarcolemma of cardiomyocytes, where it mediates Cl(−)-uptake and HCO(3)(−)-extrusion. Inhibition of AE3-mediated Cl(−)/HCO(3)(−) exchange has been suggested to protect against cardiac hypertrophy; however, other studies indicate that A...

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Huvudupphovsmän: Al Moamen, Nabeel J., Prasad, Vikram, Bodi, Ilona, Miller, Marian L., Neiman, Michelle L., Lasko, Valerie M., Alper, Seth L., Wieczorek, David F., Lorenz, John N., Shull, Gary E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019292/
https://ncbi.nlm.nih.gov/pubmed/21056571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.10.028
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