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SEMISYNTHESIS OF 6-CHLOROPURINE-2′-DEOXYRIBOSIDE 5′-DIMETHOXYTRITYL 3′-(2-CYANOETHYL-N,N-DIISOPROPYLAMINO)PHOSPHORAMIDITE AND ITS USE IN THE SYNTHESIS OF FLUORESCENTLY LABELED OLIGONUCLEOTIDES

An efficient enzymatic synthesis of 6-chloropurine-2′-deoxyriboside from the reaction of 6-chloropurine with 2′-deoxycytidine catalyzed by nucleoside-2′-deoxyribosyltransferase (E.C. 2.4.2.6) followed by chemical conversion into the 5′-dimethoxytrityl 3′-(2-cyanoethyl-N,N-diisopropylamino) phosphora...

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Hlavní autoři:	Uddin, Md. Jashim, Schulte, Michael I., Maddukuri, Leena, Harp, Joel, Marnett, Lawrence J.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	2010
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3019237/ https://ncbi.nlm.nih.gov/pubmed/21128170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770.2010.530332
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SEMISYNTHESIS OF 6-CHLOROPURINE-2′-DEOXYRIBOSIDE 5′-DIMETHOXYTRITYL 3′-(2-CYANOETHYL-N,N-DIISOPROPYLAMINO)PHOSPHORAMIDITE AND ITS USE IN THE SYNTHESIS OF FLUORESCENTLY LABELED OLIGONUCLEOTIDES

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