Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

BACKGROUND: SHANK3 is a protein in the core of the postsynaptic density (PSD) and has a critical role in recruiting many key functional elements to the PSD and to the synapse, including components of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid (AMPA), metabotropic glutamate (mGlu) and N-m...

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Detalhes bibliográficos
Main Authors: Bozdagi, Ozlem, Sakurai, Takeshi, Papapetrou, Danae, Wang, Xiaobin, Dickstein, Dara L, Takahashi, Nagahide, Kajiwara, Yuji, Yang, Mu, Katz, Adam M, Scattoni, Maria Luisa, Harris, Mark J, Saxena, Roheeni, Silverman, Jill L, Crawley, Jacqueline N, Zhou, Qiang, Hof, Patrick R, Buxbaum, Joseph D
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019144/
https://ncbi.nlm.nih.gov/pubmed/21167025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-2392-1-15
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