Reduced Excitatory Neurotransmission and Mild Autism-Relevant Phenotypes in Adolescent Shank3 Null Mutant Mice

Mutations in the synaptic scaffolding protein gene SHANK3 are strongly implicated in autism and Phelan–McDermid 22q13 deletion syndrome. The precise location of the mutation within the Shank3 gene is key to its phenotypic outcomes. Here, we report the physiological and behavioral consequences of nul...

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Detalhes bibliográficos
Main Authors: Yang, Mu, Bozdagi, Ozlem, Scattoni, Maria Luisa, Wöhr, Markus, Roullet, Florence I., Katz, Adam M., Abrams, Danielle N., Kalikhman, David, Simon, Harrison, Woldeyohannes, Leuk, Zhang, James Y., Harris, Mark J., Saxena, Roheeni, Silverman, Jill L., Buxbaum, Joseph D., Crawley, Jacqueline N.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362928/
https://ncbi.nlm.nih.gov/pubmed/22573675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6107-11.2012
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